The Johns Hopkins University School of Medicine
Department of Medicine
Division of Allergy & Clinical Immunology
Johns Hopkins Asthma & Allergy Center
5501 Hopkins Bayview Circle, Rm. 1A.20
Baltimore, MD 21224-6801
Robert G. Hamilton, Ph.D., D.ABMLI is currently Professor of Medicine and Pathology at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He joined the Division of Allergy and Clinical Immunology of the Department of Medicine in 1981 and is the Director of the Dermatology-Allergy Clinical Immunology (DACI) Reference Laboratory (link). He is a fellow of the American Academy and College of Allergy, Asthma and Immunology. He has served as co-editor the past 2 editions of the Manual of Molecular and Clinical Laboratory Immunology. He has authored more than 250 peer-reviewed publications, reviews and book chapters. He lectures extensively on a variety of topics, including laboratory diagnosis and management of human allergic disease and assessment of immunogenicity and allergenicity of new drugs.
· Humoral (antibody) immune responses in allergic and infectious disease
· Immunogenicity and allergenicity of new drugs
· Diagnostic allergy testing
· Medical product and environmental allergen testing
My current research interests focus on (1) the role of IgE and IgG antibodies in modulating human allergic disease, (2) the utility of these antibody measurements in the diagnosis and management of human allergic disease, and (3) the immunogenicity of new and FDA-approved drugs and vaccines. In 1967, IgE antibody was identified as the ‘gate-keeper’ of allergic reactions. By binding onto mast cells and basophils, it controls the release of mediators that follow allergen exposures. Our work focuses on the accurate quantification of allergen-specific IgE, IgG and IgA in an attempt to identify indicators of risk for and protection from allergic reactions. Together with my colleague N. Franklin Adkinson Jr., M.D., we are investigating the safety of new and approved drugs for their ability to elicit IgE and IgG antibody responses as part of clinical trials leading to FDA approval. Finally, I oversee the Johns Hopkins Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory which is a full service diagnostic allergy laboratory that provides IgE and IgG antibody measurements as well as measurements of indoor aeroallergens that aid in the diagnosis and management of human allergic disease.
Hamilton RG, MacGlashan DW Jr., Saini SS. IgE antibody specific activity in human allergic disease. Immunol Res. 47:273-84, 2010.
Hamilton RG, Cornish K. Immunogenicity studies of guayule and guayule latex in occupationally-exposed workers. Industrial Crops and Products 31:197-201, 2010.
Hamilton RG: Proficiency Survey Based Evaluation of Clinical Total and Allergen-Specific IgE Assay Performance. Arch Path Lab Med. 134:975-982, 2010.
Hamilton RG, Williams PB and SETT Committee: Human IgE Antibody Serology: A primer for the Practicing North American Allergist. J Allergy Clin Immunol. 126:33-8, 2010.
Hamilton RG. Diagnosis and treatment of allergy to Hymenoptera Venoms. Curr Opin Allergy Clin Immunol.10:323-9, 2010.
Hamilton RG, Mudd K, Anderson-White M, Wood RA. Extension of Food Allergen-specific IgE Ranges from the ImmunoCAP to the IMMULITE System. Ann Allergy, Asthma & Immunology 107:139-144, 2011.
Hamilton RG. Provocation tests with objective measures remain more diagnostic than surrogate immunoglobulin E antibody measures of sensitization. Clin Exp Allergy. 41:1048-9, 2011.
Updated August 2011